Tadashi Eguchi Selected Research

FD 891

1/2016	Synthesis and structure-activity relationship study of FD-891: importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells.
7/2010	Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation.
9/2009	The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells.

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Tadashi Eguchi Research Topics

Disease

4	Neoplasms (Cancer) 01/2019 - 09/2009
2	Dehydration (Water Stress) 12/2019 - 11/2015
2	Leukemia 07/2010 - 09/2009
1	Inflammation (Inflammations) 06/2021
1	Cystitis 01/2017

Drug/Important Bio-Agent (IBA)

3	FD 891IBA 01/2016 - 09/2009
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2017 - 07/2010
2	MacrolidesIBA 07/2010 - 09/2009
1	Immunoglobulin G (IgG)IBA 06/2021
1	cremimycinIBA 12/2019
1	2-acetamidoethanethiolIBA 12/2019
1	Sirolimus (Rapamycin)FDA Link 01/2019
1	MTOR InhibitorsIBA 01/2019
1	Organophosphonates (Phosphonates)IBA 01/2017
1	phosphoenolpyruvate mutaseIBA 01/2017
1	telomestatinIBA 01/2017
1	CarbonIBA 01/2017
1	Fosfomycin FDA Link 01/2017
1	Phosphorus (Red Phosphorus)IBA 01/2017
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2017
1	Epoxy Compounds (Epoxides)IBA 01/2016
1	AcidsIBA 11/2015
1	CaspasesIBA 09/2009
1	Cytochromes c (Cytochrome c)IBA 09/2009